36-156-610MG
MilliporeSigma™ Calbiochem™ GSK-3 Inhibitor IV, SB-216763
Manufacturer: MilliporeSigma™
CAS Number: 280744-09-4
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 36-156-610MG-Each-of-1 | In Stock | ₹ 20,049.27 |
36-156-610MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,049.27
GST (18%): ₹ 3,608.869
Total Price: ₹ 23,658.139
Color
Orange
CAS
280744-09-4
Formula Weight
371.2g/mol
Form
Solid
Description
98% by HPLC
Molecular Formula
C19H12Cl2N2O2
Solubility
DMSO
Quantity
10 mg
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-12012 50mg , SB 216763 CAS:280744-09-4 Purity:>98% | -- | ₹ 24,885.13 | |
| | eMolecules Medchem Express / SB 216763 / 5mg / 446260509 / HY-12012 / / 280744-09-4 / MFCD09753369 / 371.220 / C19H12Cl2N2O2 | -- | ₹ 8,312.15 | |
| | Sigma Aldrich Fine Chemicals Biosciences SB 216763 >98% (HPLC) | Purity: >98% (HPLC) | Mol Wt: 371.22 | 280744-09-4 | MFCD09753369 | 25MG | -- | ₹ 73,499.46 | |
| | Medchemexpress LLC HY-12012 5mg Medchemexpress, SB 216763 CAS:280744-09-4 Purity:>98% | -- | ₹ 5,929.31 | |
| | Enzo Life Sciences SB-216763 (5mg). CAS: 280744-09-4 | -- | ₹ 43,507.26 |
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Description
- A cell-permeable (aryl,indole) maleimide compound that acts as a potent, selective, ATP-competitive inhibitor of GSK-3 activity (K i = 9.1nM for GSK-3α)
- At 10μM concentration, does not significantly inhibit a panel of 24 other protein kinases tested
- Reported to stimulate glycogen synthesis in Chang human liver cells (EC 50 = 3.6μM) and induce transcription of β-catenin-LEF/TCF (lymphoid enhancer factor/T cell factor) regulated reporter gene in HEK293 human embryonic kidney cell lines
- Offers protection against polyglutamine-induced death in SK-N-SH and COS-7 cells and attenuates hypoxia-induced apoptosis in VSMC and COS-7 cells
- Shown to reduce phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression in hepatoma cells
- Promotes the survival of CLL lymphocytes via Wnt/β-catenin-mediated transcription activation
- Exhibits delayed cardioprotection in vivo in a rat model via a KATP (ATP-sensitive potassium channels) and MPTP (mitochondrial permeability transition pore)-dependent mechanism at reperfusion.