37-171-51MG

MilliporeSigma™ Calbiochem™ Gliotoxin, Gladiocladium fimbriatum

Manufacturer: MilliporeSigma™

CAS Number: 67-99-2

Select a Size

Pack Size SKU Availability Price
Each of 1 37-171-51MG-Each-of-1 In Stock ₹ 15,657.48

37-171-51MG - Each of 1

₹ 15,657.48

In Stock

Quantity

1

Base Price: ₹ 15,657.48

GST (18%): ₹ 2,818.346

Total Price: ₹ 18,475.826

Color

White

Target Proteins

FTase

Molecular Formula

C13H14N2O4S2

Solubility

DMSO or EtOH

Quantity

1 mg

Description

98% by TLC

CAS

67-99-2

Formula Weight

326.4g/mol

Form

Solid

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Description

  • An immunosuppressive secondary metabolite produced by several pathogenic fungi
  • Immunosuppressive effects are caused by blocking of membrane thiol groups
  • Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes
  • Farnesyltransferase (FTase) inhibitor (IC 50 = 1.1μM)
  • Reported to increase ryanodine Ca 2+ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor
  • Specifically inhibits NF-κB activation in B and T cells at nanomolar concentrations.