42-064-010MG
MilliporeSigma™ Calbiochem™ Ketohexokinase Inhibitor
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 42-064-010MG-Each-of-1 | In Stock | ₹ 24,076.58 |
42-064-010MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,076.58
GST (18%): ₹ 4,333.784
Total Price: ₹ 28,410.364
Color
Yellow
Molecular Formula
C21H26N8S·2HCl
Solubility
DMSO
Form
Solid
Description
97% by HPLC
Formula Weight
495.5g/mol
Content And Storage
Protect from light
Quantity
10 mg
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Description
- An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC 50 = 12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC 50 ≤ 400nM in HepG2 cells)
- Displays ∽50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCθ (IC 50 >> 10μM)
- Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats.