44-413-025MG
MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor, MIM1
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 44-413-025MG-Each-of-1 | In Stock | ₹ 17,823.00 |
44-413-025MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,823.00
GST (18%): ₹ 3,208.14
Total Price: ₹ 21,031.14
Color
Yellow
Target Proteins
Mcl-1
Formula Weight
347.4g/mol
Content And Storage
Protect from light
Quantity
25 mg
Description
97% by HPLC
Molecular Formula
C17H21N3O3S
Solubility
DMSO
Form
Powder
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Description
- A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-X L , antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC 50 = 4.8μM)
- Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-X L -, dependent B-ALL cultures (6% vs
- 82% survival, respectively; 10μM)
- In comparison, ABT-737 (Cat
- No
- 197333) affects only Bcl-X L -, but not Mcl-1-, dependent B-ALL cells
- Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax -/- Bak -/- MEF.