50-055-60001
MilliporeSigma™ Calbiochem™ Tankyrase1/2 Inhibitor V, WIKI4
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-055-60001-Each-of-1 | In Stock | ₹ 19,451.21 |
50-055-60001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 19,451.21
GST (18%): ₹ 3,501.218
Total Price: ₹ 22,952.428
Color
Pale Yellow
Target Proteins
TNKS2
Formula Weight
521.59g/mol
Content And Storage
Protect from light
Description
98% by HPLC
Molecular Formula
C29H23N5O3S
Solubility
DMSO
Form
Powder
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Description
- A cell-permeable triazole derivative that acts as a reversible TNKS inhibitor (IC 50 = 15nM) and selectively inhibits Wnt/β-catenin, but not NF-κB, TGFβ, or retinoic acid, signaling pathway-dependent transcription activity
- Both WIKI4 and XAV939 (Cat
- No
- 575545) are shown to induce basal axin1/2 protein accumulation in DLD1 colon cancer cells (2.5μM; 2 to 4 h) and prevent Wnt3a-induced axin1 protein degradation and β-catenin accumulation in A375 melanoma cells (1μM; up to 24 h) with similar potency
- Likewise, WIKI4 also effectively inhibits the Wnt/β-catenin pathway-dependent growth of DLD1 (by 67% in 10 days;1μM)
- Please note that the molecular weight for this compound is batch-specific due to variable water content
- Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
- The molecular weight provided represents the baseline molecular weight without water.