45-458-52MG
MilliporeSigma™ Calbiochem™ NMDA Receptor NR2BCT(1292-1304)-TAT
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 45-458-52MG-Each-of-1 | In Stock | ₹ 24,897.96 |
45-458-52MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,897.96
GST (18%): ₹ 4,481.633
Total Price: ₹ 29,379.593
Color
White
Description
98% by HPLC
Formula Weight
3382g/mol
Content And Storage
Hygroscopic, Protect from light
Quantity
2 mg
Formulation
Supplied as a trifluoroacetate salt
Molecular Formula
C143H254N64O32
Solubility
H2O
Form
Powder
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Description
- A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology
- Blocks Ca 2+ influx through extrasynaptic NMDA receptors (at 50μM) and the blood-brain-barrier permeable version, namely NR2B CT (1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.).