48-002-65MG
MilliporeSigma™ Calbiochem™ NBD-Binding Peptide II, Cell Permeable, CTP-NBD
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 48-002-65MG-Each-of-1 | In Stock | ₹ 33,813.31 |
48-002-65MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,813.31
GST (18%): ₹ 6,086.396
Total Price: ₹ 39,899.706
Color
White
Description
97% by HPLC
Formula Weight
2846.2g/mol
Content And Storage
Hygroscopic, Protect from light
Quantity
5 mg
Formulation
Supplied as a trifluoroacetate salt.
Target Proteins
NEMO-binding peptide
Solubility
H2O
Form
Solid
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Description
- A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC 50 ∽ 50μM in HCT116 cells)
- Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation
- Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities
- Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators
- Antennapedia fused NBD cell-permeable peptide is also available ( Cat
- No
- 480025).