50-484-30001
MilliporeSigma™ Calbiochem™ Fbxo3 Inhibitor, BC-1215
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-484-30001-Each-of-1 | In Stock | ₹ 23,479.38 |
50-484-30001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,479.38
GST (18%): ₹ 4,226.288
Total Price: ₹ 27,705.668
Color
Beige
Target Proteins
Fbox3
Solubility
DMSO
Form
Solid
Description
98% by HPLC
Molecular Formula
C26H26N4
Content And Storage
Protect from light
Quantity
10 mg
Related Products
Description
- A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination
- Effectively reduces cellular TRAFs (5 to 127μM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25μM)
- Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P
- aeruginosa infection in mice (100μg/mouse; i.p.) in vivo .