50-576-00001
MilliporeSigma™ Calbiochem™ HDAC6 Inhibitor II, BRD9757
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-576-00001-Each-of-1 | In Stock | ₹ 22,280.68 |
50-576-00001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,280.68
GST (18%): ₹ 4,010.522
Total Price: ₹ 26,291.202
Color
Pale Orange
Target Proteins
HDAC6
Solubility
DMSO
Form
Solid
Description
98% by HPLC
Molecular Formula
C6H9NO2
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC 50 = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC 50 = 0.638, 1.79, 0.694, and 1.09μM, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC 50 >12.61μM)
- Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 and 30μM; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat
- No
- 382187)
- Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate.