MilliporeSigma™ Calbiochem™ Divin

Description

• A cell-permeable, stable benzimidazolylpropanehydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability
• Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5μM against V
• cholerae , C
• crescentus CB15N strain and JW5503 and YJE24 strains of E
• coli , respectively)
• Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells
• Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes
• Exhibits low toxicity in mammalian cells.