50-050-80001
MilliporeSigma™ Calbiochem™ ATR Inhibitor III, ETP-46464
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-050-80001-Each-of-1 | In Stock | ₹ 24,127.92 |
50-050-80001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,127.92
GST (18%): ₹ 4,343.026
Total Price: ₹ 28,470.946
Color
White
Target Proteins
ATR
Solubility
DMSO
Form
Powder
Description
99% by HPLC
Molecular Formula
C30H22N4O2
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC 50 = 0.6, 14, 36, 170, and 545 nM, respectively) and preferentially suppresses radiation-induced cellular ATR activity (>90% at 500nM) over ATM or DNA-PK activity (IC 50 > 5μM) in U2OS cells, while exhibiting much reduced or little potency toward a panel of 26 other kinases (>55% inhibition at 5μM)
- Shown to synergize with UCN-01 (Cat
- No
- 539644) in replicative stress induction in S-phase replicating U2OS (1.5-, 61-, and 190-fold of control RS, respectively, with 1μM ETP-46464, 50nM UCN-01, or combined treatment)
- Please note that the molecular weight for this compound is batch-specific due to variable water content
- Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
- The molecular weight provided represents the baseline molecular weight without water.