50-604-50001
MilliporeSigma™ Calbiochem™ GPR55 Receptor Antagonist, CID16020046
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-604-50001-Each-of-1 | In Stock | ₹ 23,479.38 |
50-604-50001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,479.38
GST (18%): ₹ 4,226.288
Total Price: ₹ 27,705.668
Color
Off-white
Target Proteins
GPR55
Solubility
DMSO
Form
Powder
Description
99% by HPLC
Molecular Formula
C25H19N3O4
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A selective antagonist of G protein-coupled receptor 55 (GPR55) that blocks lipid L-a-lysophosphatidylinositol (LPI, Cat
- No
- 440153)-induced GPR55 activation (IC 50 = 1μM) and downstream effects in HEK293 cells
- Also shown to block the agonistic effect of LPI on GPR55- expressing yeast cells (∽10μM)
- Inhibits LPI-induced Ca2+ mobilization and ERK1/2 phosphorylation in HEK-GPR55 and HEK-CB1 cells
- However, it does not affect basal Ca2+ mobilization and ERK1/2 activity
- Blocks the GPR55-mediated NFAT and NF-kB activation and their nuclear translocation in HEK-GPR55 cells
- Diminishes LPI-induced wound healing in GPR55-expressing primary human lung microvascular endothelial cells and reverses LPI-inhibited platelet aggregation (∽10μM)
- Also reported to inhibit the activity of phosphodiesterases PDE3A and PDE4B (pIC 50 = 5 and 4.8, respectively).