50-585-40001
MilliporeSigma™ Calbiochem™ TGR5 Receptor Agonist, Cpd23g
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-585-40001-Each-of-1 | In Stock | ₹ 23,479.38 |
50-585-40001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,479.38
GST (18%): ₹ 4,226.288
Total Price: ₹ 27,705.668
Color
White
Target Proteins
TGR5
Solubility
DMSO
Form
Powder
Description
98% by HPLC
Molecular Formula
C25H25N3O2
Content And Storage
Protect from light
Quantity
10 mg
Related Products
Description
- A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC 50 = 720 pM and 6.2nM for human and mouse TGR5, respectively)
- Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120
- Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg)
- Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5 h, Cmax = 56 ng/ml; and AUC = 147 ng.h/ml following an oral dose of 5mg/kg).