56-633-110MG
MilliporeSigma™ Calbiochem™ SIRT2 Inhibitor II, AK-1
Manufacturer: MilliporeSigma™
CAS Number: 330461-64-8
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 56-633-110MG-Each-of-1 | In Stock | ₹ 16,024.53 |
56-633-110MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,024.53
GST (18%): ₹ 2,884.415
Total Price: ₹ 18,908.945
Color
Off-white
CAS
330461-64-8
Formula Weight
403.45g/mol
Form
Solid
Description
>95% by HPLC
Molecular Formula
C19H21N3O5S
Solubility
DMSO
Quantity
10 mg
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-101465 5mg Medchemexpress, AK-1 CAS:330461-64-8 Purity:>98% | -- | ₹ 4,491.90 | |
| | Sigma Aldrich Fine Chemicals Biosciences AK-1 >=98% (HPLC) | 330461-64-8 | MFCD01122550 | 5MG | -- | ₹ 12,682.56 | |
| | 330461-64-8 | AK-1 | -- | ₹ 4,449.12 - ₹ 41,924.40 |
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Description
- A cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC 50 = 12.5μM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC 50 >40μM) with much less potency
- Western analysis illustrates that treatment with AK-1 (> 25μM) leads to an increase in acetylated tubulin
- AK-1 (1 to 10μM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans
- It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1μM to 4μM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.