58-181-02MG
MilliporeSigma™ Calbiochem™ (-)-Terreic Acid, Synthetic
Manufacturer: MilliporeSigma™
CAS Number: 121-40-4
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 58-181-02MG-Each-of-1 | In Stock | ₹ 17,882.04 |
58-181-02MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,882.04
GST (18%): ₹ 3,218.767
Total Price: ₹ 21,100.807
Color
Light Beige
Target Proteins
Bruton's tyrosine kinase catalytic activity (BTK)
Molecular Formula
C7H6O4
Solubility
H2O
Form
Solid
Description
98% by HPLC
CAS
121-40-4
Formula Weight
154.2g/mol
Content And Storage
Protect from light
Quantity
2 mg
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 121-40-4 | (-)-Terreic acid | -- | ₹ 5,818.08 - ₹ 33,368.40 |
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Description
- A cell-permeable quinone epoxide antibiotic that acts as a reversible, substrate competitive, and selective inhibitor of Bruton’s tyrosine kinase catalytic activity (BTK; IC 50 = 10μM and 3μM for the basal and activation levels)
- Shown to bind to the BTK pleckstrin homology domain (BTK-PH) and block the interaction between the BTK-PH and PKC (IC 50 = ∽ 100μM in human mast cell lysates), thus affecting the catalytic activity of BTK, but not of PKC
- Selectively inhibits the autophosphorylating activity of PKC βI (IC 50 = ∽ 8μM) and not of PKC βII
- Reported to effectively inhibit the production of TNF-α (IC 50 = ∽ 3μM), and activation of JNK1 (IC 50 = ∽ 10μM) in FcεRI-stimulated mast cells
- Also inhibits the DNA synthesis in activated spleen cells (IC 50 = ∽ 1.5μM)
- Does not significantly affect the activities of Lyn, Syk, PKA, CK-1, ERK1, ERK2, and p38 kinases.