65-427-010MG

MilliporeSigma™ Calbiochem™ TNP-470

Manufacturer: MilliporeSigma™

CAS Number: 129298-91-5

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Color

White to Light Yellow

CAS

129298-91-5

Formula Weight

401.9g/mol

Form

Solid

Description

97% by HPLC

Molecular Formula

C19H28CINO6

Solubility

DMSO

Quantity

10 mg

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Description

  • A cell-permeable Fumagillin (Cat
  • No
  • 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC 50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation
  • A potent endothelial cytostasis inducer (IC 50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2 to 100mg/kg in mice and rats; s.c.).