2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate
suitable for fluorescence, BioReagent, ≥96.5% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 76204-02-9
Synonym(S): 4-MUNANA, 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid sodium salt hydrate, 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid sodium salt hydrate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | 69587-5-MG | In Stock | ₹ 32,215.20 |
| 25 MG | 69587-25-MG | In Stock | ₹ 1,37,932.15 |
69587 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 32,215.20
GST (18%): ₹ 5,798.736
Total Price: ₹ 38,013.936
product line
BioReagent
Assay
≥96.5% (HPLC)
form
powder
impurities
≤0.5% free 4-methylumbelliferone≤10% water
solubility
H2O: 50 mg/mL, clear, very slightly yellow
fluorescence
λex 315 nm; λem 374 nm (pH.7.0)λex 365 nm; λem 445 nm (after cleavage by neuraminidase)
suitability
suitable for fluorescence
storage temp.
−20°C
SMILES string
O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]
InChI
1S/C21H25NO11.Na.H2O/c1-9-5-16(27)31-15-6-11(3-4-12(9)15)32-21(20(29)30)7-13(25)17(22-10(2)24)19(33-21)18(28)14(26)8-23;;/h3-6,13-14,17-19,23,25-26,28H,7-8H2,1-2H3,(H,22,24)(H,29,30);;1H2/q;+1;/p-1/t13-,14?,17+,18?,19+,21+;;/m0../s1
Other Options
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Description
- General description: 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid or 4-MUNANA is a synthetic fluorometric substrate[1] that mimics the naturally occurring neuraminidase enzyme substrate.[2] The enzyme-substrate hydrolysis results in the product 4-methylumbelliferone (4-MU), measured fluorometrically.[2]
- Application: 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid or 4-MUNANA is used as a substrate for the development of a microplate-based assay for neuraminidase inhibitors.[3] The fluorogenic substrate 2ʹ-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid (4-MUNANA) is used to study the molecular mechanisms of aspirin and celecoxib targeting mammalian neuraminidase-1.[4]
- Biochem/physiol Actions: Substrate for fluorometric assay of neuraminidase. Used for fluorescent staining of sialidases in PAGE.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves