hLYVE-1, Mouse anti-Human, Clone: 8C, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS192925-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS192925 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
hLYVE-1
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
LYVE1;CRSBP1;HAR;XLKD1;UNQ230/PRO263
Immunogen
A recombinant fragment corresponding to the ectodomain (1-232) region of human LYVE-1.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 8C detects Lymphatic vessel endothelial hyaluronic acid receptor 1. It targets an epitope within the ectodomain region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
8C
Dilution
Immunocytochemistry Analysis: A representative lot detected hLYVE-1 in Immunocytochemistry applications (Lawrance, W., et. al. (2016). J Biol Chem. hLYVE-1; Banerji, S., et. al. (1999). J Cell Biol. 144(4):789-801). Western Blotting Analysis: A representative lot detected hLYVE-1 in Western Blotting applications (Banerji, S., et. al. (1999). J Cell Biol. 144(4):789-801; Banerji, S., et. al. (2016). J Biol Chem. 291(48):25004-25018).Flow Cytometry Analysis: A representative lot detected hLYVE-1 in Flow Cytometry applications (Lawrance, W., et. al. (2016). J Biol Chem. hLYVE-1; Banerji, S., et. al. (2016). J Biol Chem. 291(48):25004-25018).
Gene Alias
Lymphatic vessel endothelial hyaluronic acid receptor 1;Cell surface retention sequence-binding protein 1;CRSBP-1;Extracellular link domain-containing protein 1;Hyaluronic acid receptor
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Anti-hLYVE-1, clone 8C, Cat
- No
- MABS1929, is a mouse monoclonal antibody that detects Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) and has been tested for use in Flow Cytometry, Immunocytochemistry, and Western Blotting
- Lymphatic vessel endothelial hyaluronic acid receptor 1 (UniProt: Q9Y5Y7; LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1,Extracellular link domain-containing protein 1,Hyaluronic acid receptor) is encoded by the LYVE1 (also known as CRSBP1, HAR, XLKD1,UNQ230/PRO263) gene (Gene ID: 10894) in human
- LYVE-1 is a disulfide-linked, homodimeric, single-pass type I membrane protein that undergoes ligand-dependent internalization and recycling at the cell surface. It serves as a ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. It is mainly expressed in endothelial cells lining lymphatic vessels
- It is expressed on both the luminal and basolateral surfaces of lymphatic endothelium
- It is reported to mediate the uptake of intermediate and high molecular weight hyaluronan (HA) and serves as a low affinity receptor for HA-induced lymphoangiogenesis
- It also controls the entry and/or migration of leukocytes in lymphatic vessels
- The capacity of LYVE-1 to bind HA is based on a receptor distribution and organization of the glycosaminoglycans
- (Ref.: Lawrence, W et al
- (2016)
- J Biol Chem
- 291(15): 8014 8030).