K1710
Thermo Scientific™ GeneBLAzer™ M1-NFAT-blaJurkat Cells
Manufacturer: Thermo Scientific™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | K1710-Each-of-1 | In Stock | ₹ 9,05,224.80 |
K1710 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 9,05,224.80
GST (18%): ₹ 1,62,940.464
Total Price: ₹ 10,68,165.264
Accession Number
NM_000738
Cell State
Dividing Cells
Detection Method
Fluorescence
Gene Symbol
M1
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Cell Line
Jurkat
Druggable Target
GPCR
Assay Entry
Cell-based beta lactamase reporter gene
Content And Storage
LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• GeneBLAzer™ M1-NFAT-blaJurkat cells• GeneBLAzer™ M1-NFAT-blaJurkat Assay Protocol• Certificate of AnalysisThe GeneBLAzer™ M1-NFAT-blaJurkat cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
For Use With (Application)
FRET
Population Status
Single Cell Clone Origin
Quantity
5 x 106Cells
Target Entry
M1
System Type
GeneBLAzer™
Related Products
Description
- GeneBLAzer™ M1-NFAT- bla Jurkat cells contain the human Acetylcholine (muscarinic) subtype 1 receptor (M1) stably integrated into the CellSensor™ NFAT- bla Jurkat cell line
- CellSensor™ NFAT- bla Jurkat cells (Cat
- No
- K1077) contain a beta-lactamase ( bla ) reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element
- M1-NFAT- bla Jurkat cells are functionally validated for Z'-factor and EC 50 concentrations of carbachol
- In addition, M1-NFAT- bla CHO-K1 cells have been tested for assay performance under variable conditions
- These data are found in the Validation & Assay Performance Summary
- In the brain, M1 activation mediates 'slow' neuronal excitability
- Cortical and hippocampal muscarinic receptors are thought to be important in the attentional aspects of cognition
- The predominant receptor subtypes in these brain areas are M1, M3, and M4
- Therefore, M1 is a potential target for cognition, Alzheimer's, dementia, and schizophrenia
- Studies on knock-out mouse models of M1 are also beginning to reveal potential functions of the receptor
- Additional information on the muscarinic receptors can be found in reviews
- For Academic pricing please login or contact us at discoverysciences@invitrogen.com.