K1719
Thermo Scientific™ GeneBLAzer™ NMUR1-NFAT-blaCHO-K1 Cells
Manufacturer: Thermo Scientific™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | K1719-Each-of-1 | In Stock | ₹ 9,05,224.80 |
K1719 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 9,05,224.80
GST (18%): ₹ 1,62,940.464
Total Price: ₹ 10,68,165.264
Accession Number
NM_006056.2
Cell State
Dividing Cells
Detection Method
Fluorescence
Gene Symbol
NUMR1
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Cell Line
CHO-K1
Druggable Target
GPCR
Assay Entry
Cell-based beta lactamase reporter gene
Content And Storage
LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• GeneBLAzer™ NMUR1-NFAT-blaCHO-K1 cells• GeneBLAzer™ NMUR1-NFAT-blaCHO-K1 Assay Protocol• Certificate of AnalysisThe GeneBLAzer™ NMUR1-NFAT-blaCHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
For Use With (Application)
FRET
Population Status
Single Cell Clone Origin
Quantity
2 x 106Cells
Target Entry
NMUR1
System Type
GeneBLAzer™
Related Products
Description
- GeneBLAzer™ NMUR1-NFAT- bla CHO-K1 cells contain the human Neuromedin U-25 receptor 1 (NMUR1) stably integrated into the CellSensor™ NFAT- bla CHO-K1 cell line
- CellSensor™ NFAT- bla CHO-K1 cells (Cat
- No
- K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element
- The GeneBLAzer™ NMUR1-NFAT- bla CHO-K1 cells are functionally validated for Z' and EC 50 concentrations of Neuromedin U-25 In addition, GeneBLAzer™ NMUR1-NFAT- bla CHO-K1 cells have been tested for assay performance under variable conditions
- These data are found in the Validation & Assay Performance Summary
- Division Arrested cells are irreversibly division arrested using a low-dose treatment of Mitomycin C, and have no apparent toxicity or change in cellular signal transduction
- Two receptors for neuromedin U-25 have been identified through various studies and are 50% homologous to each other
- The receptors have different patterns of expression; NMUR1 localizes to the peripheral organs, including the gastrointestinal tract, urogenital system, and kidneys
- The central nervous system (CNS) was found to express much lower amounts of NMUR1 than the peripheral organ systems
- In contrast, NMUR2 is expressed primarily in the CNS
- Both receptors are believed to couple to the Gq family of proteins upon ligand binding
- The physiological roles for these receptors are unknown, but some recent animal studies have implicated NMUR1 in inflammation and the regulation of body weight and feeding
- For Academic pricing please login or contact us at discoverysciences@invitrogen.com.