K1715
Thermo Scientific™ GeneBLAzer™ AVPR1a-NFAT-blaCHO-K1 Cells
Manufacturer: Thermo Scientific™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | K1715-Each-of-1 | In Stock | ₹ 9,05,224.80 |
K1715 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 9,05,224.80
GST (18%): ₹ 1,62,940.464
Total Price: ₹ 10,68,165.264
Accession Number
NM_000706.3
Cell State
Dividing Cells
Detection Method
Fluorescence
Gene Symbol
AVPR1a
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Cell Line
CHO-K1
Druggable Target
GPCR
Assay Entry
Cell-based beta lactamase reporter gene
Content And Storage
LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• GeneBLAzer™ AVPR1a-NFAT-blaCHO-K1 cells• GeneBLAzer™ AVPR1a-NFAT-blaCHO-K1 Assay Protocol• Certificate of AnalysisThe GeneBLAzer™ AVPR1a-NFAT-blaCHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
For Use With (Application)
FRET
Population Status
Single Cell Clone Origin
Quantity
2 x 106cells
Target Entry
AVPR1A
System Type
GeneBLAzer™
Related Products
Description
- GeneBLAzer™ AVPR1a-NFAT- bla CHO-K1 cells contain the human Arginine Vasopressin Receptor 1a (AVPR1a) stably integrated into the CellSensor™ NFAT- bla CHO-K1 cell line
- CellSensor™ NFAT- bla CHO-K1 cells (Cat
- No
- K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element
- The GeneBLAzer™ AVPR1a-NFAT- bla CHO-K1 cells are functionally validated for Z' and EC 50 concentrations of Vasopressin
- In addition, GeneBLAzer™ AVPR1a-NFAT- bla CHO-K1 cells have been tested for assay performance under variable conditions
- These data are found in the Validation & Assay Performance Summary
- The family of receptors that recognize vasopressin and oxytocin consists of four members: vasopressin receptors 1a (AVPR1a), 1b (AVPR1b), and 2 (AVPR2), and the oxytocin (OT) receptor
- AVPR1a, AVPR1b, and the OT receptor couple to the Gq/G11 class of G proteins and trigger the release of intracellular calcium when stimulated
- AVPR2 receptors couple to Gs proteins and activate adenyl cyclase
- All three AVPR receptors have high affinity for their endogenous ligand, vasopressin, but AVPR1b has less affinity for oxytocin than does AVPR1a or AVPR2
- The hormones vasopressin and oxytocin are synthesized in the hypothalamus
- Oxytocin causes contractions in the uterus during childbirth
- The main functions of arginine vasopressin (AVP) are reabsorption of water by the kidneys and contraction of smooth muscle in arteries
- This system may also play a role in memory and learning
- For Academic pricing please login or contact us at discoverysciences@invitrogen.com.