92283
Polymyxin B solution
20 mg/mL in H2O
Manufacturer: Sigma Aldrich
CAS Number: 1405-20-5
Synonym(S): Aerosporin, Polymyxin B, Polymyxin B Sulfate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 ML | 92283-10-ML | In Stock | ₹ 28,675.43 |
| 125 ML | 92283-125-ML | In Stock | ₹ 5,01,598.03 |
92283 - 10 ML
In Stock
Quantity
1
Base Price: ₹ 28,675.43
GST (18%): ₹ 5,161.577
Total Price: ₹ 33,837.007
biological source
Bacillus polymyxa (fermentation)
Quality Level
200
form
liquid
optical activity
[α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
concentration
20 mg/mL in H2O
color
colorless to slightly yellow
solubility
H2O: soluble 20 mg/mL
antibiotic activity spectrum
Gram-negative bacteriaGram-positive bacteriafungi
Mode of action
cell membrane | interferes
storage temp.
2-8°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | TOKU-E Polymyxin B ReadyMade™ Solution, 1405-20-5, 10 ML | -- | ₹ 13,261.80 | |
| | Polymyxin B Solution, 1 mg/mL in Water, MilliporeSigma™ Supelco™ | -- | ₹ 10,831.90 | |
| | U.S. Pharmacopeia Polymyxin B sulphate | 1405-20-5 | 1301.6 g/mol | 200MG | -- | ₹ 28,613.83 | |
| | Polymyxin B Sulfate Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | -- | ₹ 12,200.86 | |
| | Polymyxin B Sulfate, TCI America™ | -- | ₹ 13,321.69 | |
| | Sigma Aldrich Fine Chemicals Biosciences Polymyxin B sulfate United States Pharmacopeia (USP) Reference Standard | 1405-20-5 | 200MG | -- | ₹ 45,791.71 | |
| | TOKU-E Polymyxin B Sulfate, USP, 1405-20-5, 100 MU | -- | ₹ 41,496.60 | |
| | TOKU-E Polymyxin B Sulfate, USP, 1405-20-5, 10 MU | -- | ₹ 10,780.56 | |
| | Enzo Life Sciences Polymyxin B . sulfate (1g). CAS: 1405-20-5 | -- | ₹ 8,953.85 | |
| | Polymyxin B solution | -- | ₹ 8,086.28 |
Related Products
Description
- General description: Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa.
- Application: Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.[1]
- Biochem/physiol Actions: Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium. Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.
- Packaging: 10ml, 125ml
- Preparation Note: This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.
SAFETY INFORMATION
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves