A7007
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
≥75%
Manufacturer: Sigma Aldrich
CAS Number: 86867-01-8
Synonym(S): SAM, Active methionine, AdoMet, SAM chloride dihydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | A7007-5-MG | In Stock | ₹ 7,296.05 |
| 25 MG | A7007-25-MG | In Stock | ₹ 10,781.70 |
| 100 MG | A7007-100-MG | In Stock | ₹ 23,879.95 |
| 500 MG | A7007-500-MG | In Stock | ₹ 74,735.80 |
| 1 G | A7007-1-G | In Stock | ₹ 1,23,643.15 |
A7007 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 7,296.05
GST (18%): ₹ 1,313.289
Total Price: ₹ 8,609.339
Quality Level
300
Assay
≥75%
form
powder
color
white to off-white
solubility
H2O: 100 mg/mL
application(s)
cell analysis
shipped in
dry ice
storage temp.
−20°C
SMILES string
Cl.Cl.[Cl-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI
1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;;;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);3*1H/t7-,8+,10+,11+,14+,27?;;;/m0.../s1
Other Options
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Description
- General description: S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).[1]
- Application: S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract.[2] It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.[3]
- Biochem/physiol Actions: Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
- Caution: This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.
- Analysis Note: Purity based on UV and HPLC.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable