Cytochalasin B from Drechslera dematioidea
≥98% (HPLC), powder
Manufacturer: Sigma Aldrich
CAS Number: 14930-96-2
Synonym(S): Phomin
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | C6762-1-MG | In Stock | ₹ 11,203.88 |
| 5 MG | C6762-5-MG | In Stock | ₹ 46,222.75 |
| 10 MG | C6762-10-MG | In Stock | ₹ 66,941.80 |
| 25 MG | C6762-25-MG | In Stock | ₹ 1,25,764.85 |
| 50 MG | C6762-50-MG | In Stock | ₹ 2,16,337.63 |
C6762 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 11,203.88
GST (18%): ₹ 2,016.698
Total Price: ₹ 13,220.578
Quality Level
300
Assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL
antibiotic activity spectrum
fungi
Mode of action
DNA synthesis | interferes
storage temp.
−20°C
SMILES string
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
Other Options
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Description
- General description: Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:Disruption of actin filaments and of interaction of actin filaments in solutionInhibition of actin polymerizationInhibition of subunit association and dissociationCytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.
- Biochem/physiol Actions: Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves