G2044

Glucagon

synthetic, powder, suitable for cell culture

Manufacturer: Sigma Aldrich

CAS Number: 16941-32-5

Synonym(S): GlucaGen, Glucagon peptide

Select a Size

Pack Size SKU Availability Price
1 MG G2044-1-MG In Stock ₹ 13,650.33
5 MG G2044-5-MG In Stock ₹ 36,783.35
25 MG G2044-25-MG In Stock ₹ 1,33,580.50

G2044 - 1 MG

₹ 13,650.33

In Stock

Quantity

1

Base Price: ₹ 13,650.33

GST (18%): ₹ 2,457.059

Total Price: ₹ 16,107.389

biological source

synthetic

Quality Level

200

Assay

≥95% (HPLC)

form

powder

potency

0.3-10 μg/mL

technique(s)

cell culture | mammalian: suitable

solubility

0.05 M acetic acid: 1 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

2-8°C

SMILES string

Cl[H].[H]N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)O)C(O)=O

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Description

  • Amino Acid Sequence: His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
  • General description: Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases.[1] The C-terminal region of glucagon is crucial for receptor binding.[2]
  • Application: Glucagon has been used:in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) production[3]for measuring glucagon response in mice[4]to induce gluconeogenic stimuli in primary hepatocytes[5]
  • Biochem/physiol Actions: Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood.[6] The hyperglucagonemia elevated levels of glucagon is observed in diabetes[1] and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors.[7]
  • Components: H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
  • Other Notes: This product is a chemically synthesized glucagon qualified for use in cell culture applications.
  • Physical form: powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves