G1774

Glucagon

≥95% (HPLC), powder, synthetic

Manufacturer: Sigma Aldrich

CAS Number: 16941-32-5

Select a Size

Pack Size SKU Availability Price
0.1 MG G1774-0.1-MG In Stock ₹ 24,637.70
1 MG G1774-1-MG In Stock ₹ 1,24,476.68

G1774 - 0.1 MG

₹ 24,637.70

In Stock

Quantity

1

Base Price: ₹ 24,637.70

GST (18%): ₹ 4,434.786

Total Price: ₹ 29,072.486

biological source

synthetic

Quality Level

300

sterility

non-sterile

Assay

≥95% (HPLC)

form

powder

technique(s)

cell based assay: suitable

solubility

1% acetic acid: 1.00-1.04 mg/mL, clear, colorlesswater: 1.00-1.04 mg/mL, clear, colorless

suitability

suitable for molecular biology

UniProt accession no.

P01275

shipped in

ambient

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Description

  • Amino Acid Sequence: His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
  • General description: Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets α-cells.[1]
  • Application: Glucagon (GCG) has been:used as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley rats[1]used as an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responses[4]used for the stimulation of PGC-1α expression in hepatocytes[5]used to induce the expression of methionine adenosyltransferase α1 (MAT1A), which is involved in the regulation of hepatic levels of S-adenosylmethionine and the adaptive response to fasting[6]used to study its effect on stimulation of gluconeogenesis through hepatic lipolysis, mediated by inositol trisphosphate receptor 1 (INSP3R1)[7]intraperitoneally injected in mice to assess glucagon-induced Sam68 subcellular localization in vivo[8]
  • Biochem/physiol Actions: Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles.[1] In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.[4]
  • Components: H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
  • Other Notes: Lyophilized from 0.1% TFA in H2O

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves