21-501-0R
Tocris Bioscience™ nTZDpa
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 21-501-0R-Each-of-1 | In Stock | ₹ 23,186.76 |
21-501-0R - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,186.76
GST (18%): ₹ 4,173.617
Total Price: ₹ 27,360.377
Quantity
10 mg
Product Type
nTZDpa
Molecular Weight (g/mol)
428.33
Inhibitors
nTZDpa
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Description
- Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ∽25% maximum efficacy
- Antagonizes full agonist activity by ∽60% (IC50 ∽ 285 nM)
- Displays no activity at PPARα or PPARδ receptors
- Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists
- Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .