21-505-0
Tocris Bioscience™ nTZDpa
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 21-505-0-Each-of-1 | In Stock | ₹ 94,030.44 |
21-505-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 94,030.44
GST (18%): ₹ 16,925.479
Total Price: ₹ 1,10,955.919
Purity
>98%
Product Type
nTZDpa
Inhibitors
nTZDpa
Quantity
50 mg
Molecular Weight (g/mol)
428.33
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Description
- Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ∽25% maximum efficacy
- Antagonizes full agonist activity by ∽60% (IC50 ∽ 285 nM)
- Displays no activity at PPARα or PPARδ receptors
- Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists
- Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .