5545937
Tocris Bioscience™ nTZDpa
Potent, selective PPARγ partial agonist
Manufacturer: Fischer Scientific
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Product Type
nTZDpa
Molecular Weight (g/mol)
428.33
Inhibitors
nTZDpa
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Description
- Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ∽25% maximum efficacy
- Antagonizes full agonist activity by ∽60% (IC50 ∽ 285 nM)
- Displays no activity at PPARα or PPARδ receptors
- Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists
- Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .