5545809
Tocris Bioscience™ GSK 1838705
Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
GSK 1838705
Molecular Weight (g/mol)
532.57
Inhibitors
GSK 1838705
Related Products
Description
- Potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively)
- Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5 nM)
- Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK
- Blocks proliferation of cancer cell lines in vitro , and causes complete regression of ALK-dependent tumors in vivo
- Orally bioavailable.