5545808
Tocris Bioscience™ GSK 1562590 hydrochloride
High affinity, selective urotensin II (UT) receptor antagonist
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
GSK 1562590 hydrochloride
Molecular Weight (g/mol)
617.95
Inhibitors
GSK 1562590 hydrochloride
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Description
- High affinity and selective urotensin II (UT) receptor antagonist (pKi values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively)
- Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters
- Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo
- Inhibits the hU-II-induced increase in mean blood pressure in vivo
- Orally active.