5545815
Tocris Bioscience™ GSK 429286
Selective Rho-kinase (ROCK) inhibitor
Manufacturer: Fischer Scientific
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Purity
>97%
Product Type
GSK 429286
Inhibitors
GSK 429286
Gene Alias
GSK429286A
Molecular Weight (g/mol)
432.37
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Description
- Selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively)
- Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats
- Orally active.