5545886
Tocris Bioscience™ ML 00253764 hydrochloride
Melanocortin MC4 receptor antagonist; brain penetrant
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
ML 00253764 hydrochloride
Molecular Weight (g/mol)
413.71
Inhibitors
ML 00253764 hydrochloride
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Description
- Non-peptide, melanocortin MC4 receptor antagonist (IC50 values are 320, 810 and 2120 nM for MC4, MC3 and MC5 receptors respectively)
- Decreases cAMP accumulation in HEK-293 cells expressing the MC4 receptor
- Increases food intake and reduces loss of lean body mass in tumor bearing mice
- Brain penetrant.