5546123
Tocris Bioscience™ 3PO
PFKFB3 inhibitor
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
3PO
Molecular Weight (g/mol)
210.23
Inhibitors
3PO
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Description
- Originally reported to inhibit PFKFB3 (IC50 = 25 μM)
- More recent reports failed to demonstrate activity in a PFKFB3 kinase assay
- Reduces glycolytic flux and suppresses glucose uptake
- Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro
- Attenuates vessel sprouting and tumor growth in vivo
- Amplifies the antiangiogenic effect of VEGFR blockade.