5546126
Tocris Bioscience™ A01
High affinity Smurf1 inhibitor; enhances BMP signaling
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
A01
Molecular Weight (g/mol)
512.93
Inhibitors
A01
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Description
- High affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM)
- Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling
- Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.