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MilliporeSigma™ Calbiochem™ 5-Azacytidine
Manufacturer: MilliporeSigma™
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Color
Off-white
Target Proteins
DNA & RNA
Formula Weight
244.2g/mol
Content And Storage
Hygroscopic, Protect from light
Quantity
250 mg
Description
93% by HPLC
Molecular Formula
C8H12N4O5
Solubility
DMSO or H2O
Form
Powder
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Description
- A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis
- Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage
- Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC 50 < 4.0μM)
- Enhances reprogramming efficiency (EC 50 ∽ 2.4μM in iOSKM-MEFs)
- 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat
- No
- 189825) and (Cat
- No
- 189826).