50-454-00001
MilliporeSigma™ Calbiochem™ EBP1 Inhibitor, WS6
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-454-00001-Each-of-1 | In Stock | ₹ 25,496.88 |
50-454-00001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,496.88
GST (18%): ₹ 4,589.438
Total Price: ₹ 30,086.318
Color
White
Target Proteins
EBP1/PA2G4/Erb3 binding protein-1
Solubility
DMSO or H2O
Form
Powder
Description
98% by HPLC
Molecular Formula
C29H31F3N6O3·xHCl
Content And Storage
Hygroscopic, Protect from light
Quantity
10 mg
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Description
- A cell-permeable phenoxypyrimidin-cyclopropanecarboxamide compound that effectively stimulates the growth of primary β cells in cultured primary rat and human islets in vitro (EC max in 4 d = 200 and 400 nM, respectively) and in the murine type 1 diabetes (T1D) model RIP-DTA in vivo (170% of control pancreas Ki-67-positive β cells in 1 wk; 5mg/kg i.p
- q.o.d.) by interacting with IKKε and EBP1/PA2G4/Erb3 binding protein-1 and blocking the known suppressor function of EBP1 toward E2F-mediated transcription
- Likewise, dual inhibition of EBP1 (with shRNA) and IKK (1μM; Cat
- Nos
- 401486 and 505378) is shown to fully recapitulate the proliferating effect of WS6 in R7T1 cells.