50-466-00001
MilliporeSigma™ Calbiochem™ P2X Antagonist III
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-466-00001-Each-of-1 | In Stock | ₹ 24,897.96 |
50-466-00001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,897.96
GST (18%): ₹ 4,481.633
Total Price: ₹ 29,379.593
Color
White
Target Proteins
P2X7
Solubility
DMSO
Form
Powder
Description
98% by HPLC
Molecular Formula
C28H32N4O2S
Content And Storage
Protect from light
Quantity
10 mg
Related Products
Description
- A phenylthio-nicotinamide that acts as a high affinity P2X 7 antagonist (pKi = 8.7 and 7.9, respectively, against 30nM A-804598 for rat and human P2X 7 binding) and potently inhibits P2X 7 -dependent cellular Ca 2+ mobilization (pIC 50 = 8.3, 7.5, and 7.2, respectively, using 1321N1 expressing human, mouse, or rat P2X 7 ; drug added 0.5 h prior to 3 min 0.25mm BzATP stimulation), while exhibiting much reduced or little potency toward a panel of 50 ion channels, transporters, and receptors
- Although not suitable for oral dosing due to high hepatic extraction ratios, effective delivery and brain P2X 7 occupancy can be achieved via s.c
- dosing in rats (30mg/kg) in vivo .