64-589-010MG
MilliporeSigma™ Calbiochem™ Trio N-Terminal RhoGEF Domain Inhibitor, ITX3
Manufacturer: MilliporeSigma™
CAS Number: 347323-96-0
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 64-589-010MG-Each-of-1 | In Stock | ₹ 14,736.00 |
64-589-010MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,736.00
GST (18%): ₹ 2,652.48
Total Price: ₹ 17,388.48
Color
Yellow
CAS
347323-96-0
Formula Weight
371.5g/mol
Content And Storage
Protect from light
Quantity
10 mg
Description
95% by HPLC
Molecular Formula
C22H17N3OS
Solubility
DMSO
Form
Solid
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences ITX3 >=98% (HPLC) | 347323-96-0 | MFCD02629172 | 5MG | -- | ₹ 11,634.45 | |
| | Sigma Aldrich Fine Chemicals Biosciences ITX3 >=98% (HPLC) | 347323-96-0 | MFCD02629172 | 25MG | -- | ₹ 31,233.68 | |
| | eMolecules Medchem Express / ITX3 / 5mg / 446267620 / HY-16663 / / 347323-96-0 / MFCD02629172 / 371.460 / C22H17N3OS | -- | ₹ 9,320.05 | |
| | 347323-96-0 | (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one | -- | ₹ 7,358.16 - ₹ 46,287.96 |
Related Products
Description
- A cell-permeable thiazolo-benzimidazolone compound that inhibits Trio N-terminal RhoGEF domain- (TrioN) mediated RhoG activation (IC 50 = 76μM) and effectively reduces cellular Rac activation (by 80% with 50μM ITX3) caused by TrioN, but not GEF337 (RhoA GEF), Tiam1 (Rac GEF), or Vav2 (Rac1/RhoA/Cdc42 GEF), overexpression in HEK293T cells
- Culture treatment of ITX at 100μM is shown to reduce NGF-induced neurite outgrowth of rat PC12 pheochromocytoma cells by 50% and block the formation of multinucleated myotubes by 78% in C2C12 mouse myoblasts cultures induced for differentiation, while the differentiation-associated Myogenin and Troponin T expressions in Trio knock-down C2C12 cells are not affected by ITX at the same concentration.