65-841-15MG
MilliporeSigma™ Calbiochem™ InSolution™ AG490
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 65-841-15MG-Each-of-1 | In Stock | ₹ 8,005.85 |
65-841-15MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 8,005.85
GST (18%): ₹ 1,441.053
Total Price: ₹ 9,446.903
Formulation
A 100 mM (5mg/170μl) solution of AG490 in DMSO.
Molecular Formula
C17H14N2O3
Content And Storage
Hygroscopic, Protect from light
Quantity
5 mg
Description
98% by HPLC
Formula Weight
294.3g/mol
Form
Liquid
Related Products
Description
- Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC 50 = 100nM)
- Jak family tyrosine kinase inhibitor
- Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis
- Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells
- AG 490 has also been shown to inhibit the autokinase activity of JAK3
- Also reported to inhibit guanylyl cyclase.