65-854-81MG
MilliporeSigma™ Calbiochem™ InSolution™ AG 1478
Manufacturer: MilliporeSigma™
CAS Number: 175178-82-2
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 65-854-81MG-Each-of-1 | In Stock | ₹ 10,540.14 |
65-854-81MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 10,540.14
GST (18%): ₹ 1,897.225
Total Price: ₹ 12,437.365
Color
Clear to Faint Tan
Description
98% by HPLC
CAS
175178-82-2
Formula Weight
315.8g/mol
Form
Liquid
Formulation
A 10 mM (1mg/317μl) solution of AG 1478 in DMSO.
Target Proteins
Epidermal growth factor receptor kinase
Molecular Formula
C16H14ClN3O2
Content And Storage
Protect from light
Quantity
1 mg
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences Tyrphostin AG 1478 >=98% | 175178-82-2 | MFCD00270914 | 1MG | -- | ₹ 8,239.43 | |
| | Sigma Aldrich Fine Chemicals Biosciences Tyrphostin AG 1478 | 175178-82-2 | MFCD00270914 | 5 mg | -- | ₹ 24,525.77 | |
| | 175178-82-2 | AG 1478 | -- | ₹ 15,914.16 |
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Description
- Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC 50 = 3nM)
- Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 ( neu/erb -B2) receptor (IC 50 > 100μM), the platelet-derived growth factor (PDGF) receptor (IC 50 > 100μM), and p210 Bcr-Abl (IC 50 >50μM)
- Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.