P2141

Phalloidin Peptide

≥90% (HPLC), powder

Manufacturer: Sigma Aldrich

CAS Number: 17466-45-4

Synonym(S): 28-(2,3-dihydroxy-2-methylpropyl)-18-hydroxy-34-(1-hydroxyethyl)-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone

Select a Size

Pack Size SKU Availability Price
1 MG P2141-1-MG In Stock ₹ 31,327.55

P2141 - 1 MG

₹ 31,327.55

In Stock

Quantity

1

Base Price: ₹ 31,327.55

GST (18%): ₹ 5,638.959

Total Price: ₹ 36,966.509

product name

Phalloidin from Amanita phalloides, ≥90%

biological source

Amanita phalloides

Quality Level

200

Assay

≥90%

form

powder

SMILES string

CC(O)C1NC(=O)C(C)NC(=O)C(CC(C)(O)CO)NC(=O)C2Cc3c(SCC(NC1=O)C(=O)N4CC(O)CC4C(=O)NC(C)C(=O)N2)[nH]c5ccccc35

InChI

1S/C35H48N8O11S/c1-15-27(47)38-22-10-20-19-7-5-6-8-21(19)41-33(20)55-13-24(34(53)43-12-18(46)9-25(43)31(51)37-15)40-32(52)26(17(3)45)42-28(48)16(2)36-30(50)23(39-29(22)49)11-35(4,54)14-44/h5-8,15-18,22-26,41,44-46,54H,9-14H2,1-4H3,(H,36,50)(H,37,51)(H,38,47)(H,39,49)(H,40,52)(H,42,48)

InChI key

KPKZJLCSROULON-UHFFFAOYSA-N

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Description

  • General description: Phalloidin is a phallotoxin produced by death cap mushroom Amanita phalloides. It is a cyclic peptide, which interacts with actin, and this was first identified in phalloidin-poisoned rats. It is a heptapeptide, cyclic in nature, with a crosslink between tryptophan at position 6 and cysteine at position 3.[1] The side chain of amino acid 7 (γ-δ-dihydroxyleucine) in phalloidin, is accessible to modifications, through which fluorescently labeled phalloidin compounds can be produced.[2]
  • Application: Phalloidin has been used: As a supplement in PEM buffer and dimethyl sulfoxide (DMSO).[3]As a drug.[4]In immunohistochemistry to stain F-actin.[5]
  • Biochem/physiol Actions: Phalloidin interacts with polymeric actin, and not oligomeric or monomeric forms. This interaction leads to highly stabilized actin filaments, which resist depolymerization and disassembly. In rats, this toxin causes death due to liver hemorrhage and cells show abnormal actin clustering.[1] The affinity of phalloidin to actin is not significantly altered after derivatizing fluorescently labelled phalloidin compounds. These compounds can be used to study actin structure and organization within eukaryotic cells.[2]

SAFETY INFORMATION

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Precautionary Statements

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable