5546116
Tocris Bioscience™ Z-Guggulsterone
Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
Z-Guggulsterone
Molecular Weight (g/mol)
312.45
Inhibitors
Z-Guggulsterone
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Description
- Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM)
- Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway
- Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo
- More active isomer of guggulsterone (Cat
- No
- 2013).