5546131
Tocris Bioscience™ AEE 788
Potent EGFR and VEGFR inhibitor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
AEE 788
Molecular Weight (g/mol)
440.58
Inhibitors
AEE 788
Related Products
Description
- Potent EGFR and VEGFR inhibitor (IC50 values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively)
- Also inhibits c-Abl, c-Fms and c-Src (IC50 values are 52, 60 and 61 nM respectively)
- Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro
- Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice
- Orally active.