50-638-40001
MilliporeSigma™ Calbiochem™ BLM Helicase Inhibitor, ML216
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-638-40001-Each-of-1 | In Stock | ₹ 14,929.36 |
50-638-40001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,929.36
GST (18%): ₹ 2,687.285
Total Price: ₹ 17,616.645
Color
Orange
Target Proteins
BLM
Solubility
DMSO
Form
Solid
Description
97% by HPLC
Molecular Formula
C15H9F4N5OS
Content And Storage
Protect from light
Quantity
10 mg
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Description
- A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom′s syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM 636-1298 forms (IC 50 = 2.98 and 0.97μM, respectively)
- Competes with and reversibly blocks DNA binding to BLM
- However, the inhibition appears to be non-competitive with respect to ATP
- Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM
- Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin (Cat
- No
- 178273) without affecting PSNG13 cells that are devoid of BLM
- Displays favorable microsomal (T 1/2 > 1.2 h) and plasma stability (∽100% at 5 h).